Inflammation And Cardiovascular Disease: Key Markers To Test

Identifying Inflammation’s Role in Cardiovascular Disease

Inflammation is a natural and essential part of the body’s immune response to infection, injury, or exposure to toxins. In the short term, inflammation is protective and necessary for healing. However, when inflammation becomes chronic and unresolved, it can quietly damage tissues and significantly increase the risk of chronic disease—particularly cardiovascular disease.

Chronic inflammation within the cardiovascular system has been linked to high blood pressure, elevated cholesterol, atherosclerosis (plaque buildup in the arteries), stroke, and heart attack. Understanding and testing key inflammatory and nutrient markers can provide valuable insight into cardiovascular risk long before symptoms appear.

Key Inflammatory Markers Linked to Cardiovascular Disease

Two of the most clinically relevant inflammatory markers associated with cardiovascular risk are homocysteine and high-sensitivity C-reactive protein (hs-CRP).

Homocysteine is an amino acid produced during normal metabolic processes and plays a role in the recycling of B vitamins, particularly B6, B12, and folate. When homocysteine levels become elevated, it can damage the lining of blood vessels, increase oxidative stress, and promote blood clot formation. Research has shown that high homocysteine levels are associated with an increased risk of heart disease, stroke, and other vascular conditions.

hs-CRP is a protein produced by the liver in response to systemic inflammation. Even mildly elevated hs-CRP levels over time can signal ongoing inflammation within the arteries. Persistently high hs-CRP is strongly associated with the development of atherosclerosis and an increased risk of heart attack and cardiovascular events.

Nutrient Markers That Support Heart Health and Reduce Inflammation

In addition to inflammatory markers, certain nutrient levels play a critical role in cardiovascular protection—most notably vitamin D and omega-3 fatty acids.

Vitamin D is essential for immune regulation, blood pressure control, and inflammatory balance. Low vitamin D levels have been associated with increased cardiovascular risk, higher blood pressure, and systemic inflammation. Optimizing vitamin D levels may help reduce inflammatory burden while supporting overall cardiovascular and immune health.

Omega-3 fatty acids, commonly found in fatty fish, seafood, and flaxseeds, are well known for their anti-inflammatory and cardioprotective properties. Omega-3s help reduce inflammation, support healthy blood vessels, improve lipid profiles, and decrease triglyceride levels.

Nuts are generally higher in omega-6 fatty acids than omega-3s, though the exact balance depends on the type of nut.

As part of a comprehensive omega fatty acid panel, omega-6 fatty acids are also evaluated. While omega-6 fatty acids are essential for health, excessive intake—or an imbalanced omega-6 to omega-3 ratio—can promote inflammation and oxidative stress. Maintaining an optimal balance between omega-3 and omega-6 fatty acids is key to reducing cardiovascular inflammation.

Testing and Prevention: A Proactive Approach to Cardiovascular Health

Homocysteine, hs-CRP, vitamin D, and omega fatty acid profiles can all be assessed through simple blood testing. Identifying elevations in inflammatory markers while addressing nutrient deficiencies allows for a more personalized and preventative approach to cardiovascular care.

By lowering homocysteine and hs-CRP levels and optimizing vitamin D and omega-3 status, individuals may reduce inflammation, support arterial health, and lower their long-term risk of cardiovascular disease. A proactive, root-cause approach to inflammation not only supports heart health but also promotes overall longevity and well-being.

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Author: Dr. Caitlan Readhead, ND

Disclaimer:

This information is generalized and intended for educational purposes only. Due to potential individual contraindications, please see your primary care provider before implementing any strategies in these posts.